The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import

The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import

Abstract Background The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function. All IMS proteins are nuclear encoded and synthesized in the cytosol and must therefore be correctly targeted an...

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Bibliographic Details
Main Authors: Lena Maria Murschall, Anne Gerhards, Thomas MacVicar, Esra Peker, Lidwina Hasberg, Stephan Wawra, Thomas Langer, Jan Riemer
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Biology
Subjects:
MIA40
Negatively charged C-terminus
Mitochondrial precursor
Mitochondrial import
Disulfide relay
Proteasomal degradation
Online Access:http://link.springer.com/article/10.1186/s12915-020-00824-1

Internet

http://link.springer.com/article/10.1186/s12915-020-00824-1

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