Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.

Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.

Activation of K-ras and inactivation of p16 are the most frequently identified genetic alterations in human pancreatic epithelial adenocarcinoma (PDAC). Mouse models engineered with mutant K-ras and deleted p16 recapitulate key pathological features of PDAC. However, a human cell culture transformat...

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Bibliographic Details
Main Authors: Zhe Chang, Huaiqiang Ju, Jianhua Ling, Zhuonan Zhuang, Zhongkui Li, Huamin Wang, Jason B Fleming, James W Freeman, Dihua Yu, Peng Huang, Paul J Chiao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4100754?pdf=render

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http://europepmc.org/articles/PMC4100754?pdf=render

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