Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis.

Synaptic transmission and plasticity mediated by NMDA receptors (NMDARs) could modulate the severity of multiple sclerosis (MS). Here the role of NMDARs in MS was first explored in 691 subjects carrying specific allelic variants of the NR1 subunit gene or of the NR2B subunit gene of this glutamate r...

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Main Authors: Silvia Rossi, Valeria Studer, Alessandro Moscatelli, Caterina Motta, Giancarlo Coghe, Giuseppe Fenu, Stacy Caillier, Fabio Buttari, Francesco Mori, Francesca Barbieri, Maura Castelli, Valentina De Chiara, Fabrizia Monteleone, Raffaele Mancino, Giorgio Bernardi, Sergio E Baranzini, Maria G Marrosu, Jorge R Oksenberg, Diego Centonze
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3696106?pdf=render