| Summary: | Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Low-density lipoprotein receptor (LDLR) plays a critical role in plasma lipoprotein hemostasis, which is involved in the formation of atherosclerotic plaque. This study aimed to evaluate whether <i>LDLR</i> gene polymorphisms are significantly associated with ACS and the plasma lipids profile. Three <i>LDLR</i> gene polymorphisms located in the <i>UTR′3</i> region (c.*52 <i>A/G</i>, c.*504 <i>A/G</i>, and c.* 773 <i>A/G</i>) were determined using TaqMan genotyping assays in a group of 618 ACS patients and 666 healthy controls. Plasma lipids profile concentrations were determined by enzymatic/colorimetric assays. Under co-dominant and recessive models, the <i>c.*52 A</i> allele of the <i>c.*52 A/G</i> polymorphism was associated with a higher risk of ACS (OR = 2.02, <i>pC</i><sub>Co-dom</sub> = 0.033, and OR = 2.00, <i>pC</i><sub>Res</sub> = 0.009, respectively). In the same way, under co-dominant and recessive models, the <i>c.*773 G</i> allele of the <i>c.*773 A/G</i> polymorphism was associated with a high risk of ACS (OR = 2.04, <i>pC</i><sub>Co-dom</sub> = 0.027, and OR = 2.01, <i>pC</i><sub>Res</sub> = 0.007, respectively). The “<i>AAG”</i> haplotype was associated with a high risk of ACS (OR = 1.22, <i>pC</i> = 0.016). The <i>c.*52 AA</i> genotype showed a lower HDL-C concentration than individuals with the <i>GG</i> genotype. In addition, carriers of <i>c.*773 GG</i> genotype carriers had a lower concentration of the high-density lipoprotein-cholesterol (HDL-C) than subjects with the <i>AA</i> genotype. Our data suggest the association of the <i>LDLR</i><i>c.*773 A/G</i> and <i>LDLR c.*52 A/G</i> polymorphisms with both the risk of developing ACS and with a lower concentration of HDL-C in the study population.
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