Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype.

Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype.

Although HIV infection inhibits interferon responses in its target cells in vitro, interferon signatures can be detected in vivo soon after sexual transmission, mainly attributed to plasmacytoid dendritic cells (pDCs). In this study, we examined the physiological contributions of pDCs to early HIV a...

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Bibliographic Details
Main Authors: Orion Tong, Gabriel Duette, Thomas R O'Neil, Caroline M Royle, Hafsa Rana, Blake Johnson, Nicole Popovic, Suat Dervish, Michelle A E Brouwer, Heeva Baharlou, Ellis Patrick, Grahame Ctercteko, Sarah Palmer, Eunok Lee, Eric Hunter, Andrew N Harman, Anthony L Cunningham, Najla Nasr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009522

Internet

https://doi.org/10.1371/journal.ppat.1009522

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