microRNA-126 Is a Tumor Suppressor of Granulosa Cell Tumor Mediated by Its Host Gene EGFL7

microRNA-126 Is a Tumor Suppressor of Granulosa Cell Tumor Mediated by Its Host Gene EGFL7

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at a post-transcriptional level. We examined the role of miR-126 in granulosa cell tumor (GCT) of the ovaries. In tissues from malignant GCT patients miR-126 expression was repressed. We showed that miR-126 could inhibit proli...

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Bibliographic Details
Main Authors: Jiajie Tu, Hoi-Hung Cheung, Gang Lu, Clement Leung-Kwok Chan, Zijiang Chen, Wai-Yee Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Oncology
Subjects:
miR-126
GCT
EGFL7
AKT pathway
tumoriogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00486/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00486/full

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