Loss of <i>AMPKα2</i> Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis

Loss of <i>AMPKα2</i> Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that has a dual role in cancer, i.e., pro- or anti-tumorigenic, depending on the context. In medulloblastoma, the most frequent malignant pediatric brain tumor, several in vitro studies previously showed that AMPK suppress...

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Bibliographic Details
Main Authors: Honglai Zhang, Rork Kuick, Sung-Soo Park, Claire Peabody, Justin Yoon, Ester Calvo Fernández, Junying Wang, Dafydd Thomas, Benoit Viollet, Ken Inoki, Sandra Camelo-Piragua, Jean-François Rual
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
medulloblastoma
sonic hedgehog
AMPK
Online Access:https://www.mdpi.com/1422-0067/19/11/3287

Internet

https://www.mdpi.com/1422-0067/19/11/3287

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