Multi-Facial, Non-Peptidic α-Helix Mimetics

α-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix.

Bibliographic Details
Main Authors: Maryanna E. Lanning, Steven Fletcher
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Biology
Subjects:
Bak
Bim
p53
Online Access:http://www.mdpi.com/2079-7737/4/3/540