Heterogeneity and Actin Cytoskeleton in Osteoclast and Macrophage Multinucleation

Heterogeneity and Actin Cytoskeleton in Osteoclast and Macrophage Multinucleation

Osteoclast signatures are determined by two transcriptional programs, the lineage-determining transcription pathway and the receptor activator of nuclear factor kappa-B ligand (RANKL)-dependent differentiation pathways. During differentiation, mononuclear precursors become multinucleated by cell fus...

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Bibliographic Details
Main Authors: Jiro Takito, Masanori Nakamura
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
actin
fusion
environment-dependent signaling
foreign body giant cells
macrophage
mechanotransduction
Online Access:https://www.mdpi.com/1422-0067/21/18/6629

Internet

https://www.mdpi.com/1422-0067/21/18/6629

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