The Role of IGF/IGF-IR-Signaling and Extracellular Matrix Effectors in Bone Sarcoma Pathogenesis

The Role of IGF/IGF-IR-Signaling and Extracellular Matrix Effectors in Bone Sarcoma Pathogenesis

Bone sarcomas, mesenchymal origin tumors, represent a substantial group of varying neoplasms of a distinct entity. Bone sarcoma patients show a limited response or do not respond to chemotherapy. Notably, developing efficient chemotherapy approaches, dealing with chemoresistance, and preventing meta...

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Bibliographic Details
Main Authors: George N. Tzanakakis, Eirini-Maria Giatagana, Aikaterini Berdiaki, Ioanna Spyridaki, Kyoko Hida, Monica Neagu, Aristidis M. Tsatsakis, Dragana Nikitovic
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
bone sarcoma
IGF signaling
IGF-1R
extracellular matrix
tumor microenvironment
cancer therapy
Online Access:https://www.mdpi.com/2072-6694/13/10/2478

Internet

https://www.mdpi.com/2072-6694/13/10/2478

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