Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome

Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome

Angelman syndrome (AS) is a neurodevelopmental disorder largely due to abnormal maternal expression of the UBE3A gene leading to the deletion of E6-associated protein. AS subjects have severe cognitive impairments for which there are no therapeutic interventions. Mouse models (knockouts of the mater...

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Bibliographic Details
Main Authors: Michel Baudry, Eniko Kramar, Xiaobo Xu, Homera Zadran, Stephanie Moreno, Gary Lynch, Christine Gall, Xiaoning Bi
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Neurobiology of Disease
Subjects:
Actin
AMPA receptor
Hippocampus
Learning and memory
LTP
UBE3A
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112001313

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http://www.sciencedirect.com/science/article/pii/S0969996112001313

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