DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis

DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis

Abstract Background The mammalian target of rapamycin (mTOR) pathway plays a significant role in osteogenic differentiation and bone maintenance. As the only known endogenous inhibitor of mTOR function, DEP domain containing mTOR interacting protein (DEPTOR) is potentially involved in stem cell diff...

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Bibliographic Details
Main Authors: Si Chen, Lingfei Jia, Shan Zhang, Yunfei Zheng, Yongsheng Zhou
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Stem Cell Research & Therapy
Subjects:
DEP domain containing mTOR interacting protein
Osteoporosis
Osteogenesis
Maternally expressed 3 (nonprotein coding)
Bone morphogenetic protein 4
Bone engineering
Online Access:http://link.springer.com/article/10.1186/s13287-018-0935-9

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http://link.springer.com/article/10.1186/s13287-018-0935-9

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