Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice

Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice

Overnutrition activates a proinflammatory program in macrophages to induce insulin resistance (IR), but its molecular mechanisms remain incompletely understood. Here, we show that saturated fatty acid and lipopolysaccharide, two factors implicated in high-fat diet (HFD)-induced IR, suppress macropha...

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Bibliographic Details
Main Authors: Hongming Miao, Juanjuan Ou, Yinyan Ma, Feng Guo, Zhenggang Yang, Melvin Wiggins, Chaohong Liu, Wenxia Song, Xianlin Han, Miao Wang, Qiang Cao, Bik-Ho Florence Chung, Dan Yang, Houjie Liang, Bingzhong Xue, Hang Shi, Lixia Gan, Liqing Yu
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714001636

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http://www.sciencedirect.com/science/article/pii/S2211124714001636

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