Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

Mitochondrial transport toward both the plus- and minus-ends of microtubules is mediated by motor proteins linked to mitochondria by TRAK adaptor proteins. Here the authors investigate the role of TRAK2 as a bidirectional motor adaptor, and propose a model where TRAK2 coordinates the activities of o...

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Bibliographic Details
Main Authors: Adam R. Fenton, Thomas A. Jongens, Erika L. F. Holzbaur
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24862-7