Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.

Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.

Development of viral vectors capable of transducing photoreceptors by less invasive methods than subretinal injection would provide a major advancement in retinal gene therapy. We sought to develop novel AAV vectors optimized for photoreceptor transduction following intravitreal delivery and to deve...

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Bibliographic Details
Main Authors: Christine N Kay, Renee C Ryals, George V Aslanidi, Seok Hong Min, Qing Ruan, Jingfen Sun, Frank M Dyka, Daniel Kasuga, Andrea E Ayala, Kim Van Vliet, Mavis Agbandje-McKenna, William W Hauswirth, Sanford L Boye, Shannon E Boye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3637363?pdf=render

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http://europepmc.org/articles/PMC3637363?pdf=render

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