Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy

Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy

Impairment of the ubiquitin-proteasome-system (UPS) and autophagy causing cytoplasmic aggregation of ubiquitin andp62 have been implicated in the pathogenesis of most neurodegenerative disorders, yet, they have not been fully elucidated in leukodystrophies. The relationship among impairment of UPS,...

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Bibliographic Details
Main Authors: Dar-Shong Lin, Che-Sheng Ho, Yu-Wen Huang, Tsu-Yen Wu, Tsung-Han Lee, Zo-Darr Huang, Tuan-Jen Wang, Shun-Jie Yang, Ming-Fu Chiang.
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
leukodystrophies
globoid cell leukodystrophy
psychosine
autophagy
p62
ubiquitin
Online Access:https://www.mdpi.com/2073-4409/9/5/1124

Internet

https://www.mdpi.com/2073-4409/9/5/1124

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