Pharmacokinetics of H002, a novel S1PR1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry

Pharmacokinetics of H002, a novel S1PR1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry

A rapid and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous determination of H002 and its phosphorylated metabolite, H002-P and hydroxylated metabolite H002-M, in rat blood. H001, an analogue of H002, was used as the interna...

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Bibliographic Details
Main Authors: Jiaqi Mi, Manman Zhao, Shu Yang, Shuang Yang, Jing Jin, Xiaojian Wang, Qiong Xiao, Jinping Hu, Yan Li
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
S1P receptor
S1PR1 modulator
Sphingosine-1-phosphate
S1P analogue
Metabolite
LC–MS/MS
Pharmacokinetics
Periphery blood lymphocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515300435

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http://www.sciencedirect.com/science/article/pii/S2211383515300435

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