Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

Background: Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to the injury that involves the neurohumoral, in...

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Bibliographic Details
Main Authors: Pär I Johansson, Nis A Windeløv, Lars S Rasmussen, Anne Marie Sørensen, Sisse R Ostrowski
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Emergencies, Trauma and Shock
Subjects:
Coagulopathy
deoxyribonucleic acid
histones
nucleic acids
tissue injury
trauma
Online Access:http://www.onlinejets.org/article.asp?issn=0974-2700;year=2013;volume=6;issue=3;spage=171;epage=175;aulast=Johansson

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http://www.onlinejets.org/article.asp?issn=0974-2700;year=2013;volume=6;issue=3;spage=171;epage=175;aulast=Johansson

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