SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.

SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.

Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellular processes including integrin-mediated cell adhesion, cell signaling pathways, and extracellular matrix assem...

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Bibliographic Details
Main Authors: Meghan A Morrissey, Ranjay Jayadev, Ginger R Miley, Catherine A Blebea, Qiuyi Chi, Shinji Ihara, David R Sherwood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4771172?pdf=render

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http://europepmc.org/articles/PMC4771172?pdf=render

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