Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

In this study the role of P2Y12 receptors (P2Y12R) was explored in rodent models of inflammatory and neuropathic pain and in acute thermal nociception. In correlation with their activity to block the recombinant human P2Y12R, the majority of P2Y12R antagonists alleviated mechanical hyperalgesia dose...

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Bibliographic Details
Main Authors: Gergely Horváth, Flóra Gölöncsér, Cecilia Csölle, Kornél Király, Rómeó D. Andó, Mária Baranyi, Bence Koványi, Zoltán Máté, Kristina Hoffmann, Irina Algaier, Younis Baqi, Christa E. Müller, Ivar Von Kügelgen, Beáta Sperlágh
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Neurobiology of Disease
Subjects:
P2Y12 receptor
Purine receptor
Inflammatory pain
Neuropathic pain
Spinal cord
Interleukin-1β
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001752

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http://www.sciencedirect.com/science/article/pii/S0969996114001752

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