Antibody-Dependent Cell-Mediated Cytotoxicity Effector-Enhanced EphA2 Agonist Monoclonal Antibody Demonstrates Potent Activity against Human Tumors

Antibody-Dependent Cell-Mediated Cytotoxicity Effector-Enhanced EphA2 Agonist Monoclonal Antibody Demonstrates Potent Activity against Human Tumors

EphA2 is a receptor tyrosine kinase that has been shown to be overexpressed in a variety of human tumor types. Previous studies demonstrated that agonist monoclonal antibodies targeting EphA2 induced the internalization and degradation of the receptor, thereby abolishing its oncogenic effects. In t...

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Bibliographic Details
Main Authors: Elizabeth M. Bruckheimer, Christine A. Fazenbaker, Sandra Gallagher, Kathy Mulgrew, Stacy Fuhrmann, Karen T. Coffman, William Walsh, Shannon Ready, Kim Cook, Melissa Damschroder, Michael Kinch, Peter A. Kiener, Rob Woods, Changshou Gao, William Dall'Acqua, Herren Wu, Steven Coats
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609801085

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http://www.sciencedirect.com/science/article/pii/S1476558609801085

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