Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer.

Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer.

Prostate cancer (CaP) is the second leading cause of cancer death in American men. Androgen deprivation therapy is initially effective in CaP treatment, but CaP recurs despite castrate levels of circulating androgen. Continued expression of the androgen receptor (AR) and its ligands has been linked...

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Bibliographic Details
Main Authors: Mark A Titus, Brian Zeithaml, Boris Kantor, Xiangping Li, Karin Haack, Dominic T Moore, Elizabeth M Wilson, James L Mohler, Tal Kafri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3260230?pdf=render

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http://europepmc.org/articles/PMC3260230?pdf=render

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