SARS-CoV-2 Spike Protein-Directed Monoclonal Antibodies May Ameliorate COVID-19 Complications in APECED Patients

SARS-CoV-2 Spike Protein-Directed Monoclonal Antibodies May Ameliorate COVID-19 Complications in APECED Patients

Patients with the monogenic immune dysregulatory syndrome autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), which is caused by loss-of-function mutations in the autoimmune regulator (AIRE) gene, uniformly carry neutralizing autoantibodies directed against type-I interferons (I...

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Bibliographic Details
Main Authors: Elise M. N. Ferré, Monica M. Schmitt, Sebastian Ochoa, Lindsey B. Rosen, Elana R. Shaw, Peter D. Burbelo, Jennifer L. Stoddard, Shakuntala Rampertaap, Tom DiMaggio, Jenna R. E. Bergerson, Sergio D. Rosenzweig, Luigi D. Notarangelo, Steven M. Holland, Michail S. Lionakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
APECED
APS-1
AIRE
type-1 IFN autoantibodies
pneumonitis
COVID-19
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.720205/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.720205/full

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