Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases
As an adaptive response to the overloading with misfolded proteins in the endoplasmic reticulum (ER), ER stress plays critical roles in maintaining protein homeostasis in the secretory pathway to avoid damage to the host. Such a conserved mechanism is accomplished through three well-orchestrated pat...
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2014-07-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00242/full |
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doaj-acd9d2df6da844c8a200f8677219b8512020-11-24T22:29:55ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-07-01510.3389/fgene.2014.00242102163Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseasesBeichu eGuo0Zihai eLi1Medical University of South CarolinaMedical University of South CarolinaAs an adaptive response to the overloading with misfolded proteins in the endoplasmic reticulum (ER), ER stress plays critical roles in maintaining protein homeostasis in the secretory pathway to avoid damage to the host. Such a conserved mechanism is accomplished through three well-orchestrated pathways known collectively as unfolded protein response (UPR). Persistent and pathological ER stress has been implicated in a variety of diseases in metabolic, inflammatory and malignant conditions. Furthermore, ER stress is directly linked with inflammation through UPR pathways, which modulate transcriptional programs to induce the expression of inflammatory genes. Importantly, the inflammation induced by ER stress is directly responsible for the pathogenesis of metabolic and inflammatory diseases. In this review, we will discuss the potential signaling pathways connecting ER stress with inflammation. We will also depict the interplay between ER stress and inflammation in the pathogenesis of hepatic steatosis, inflammatory bowel diseases and colitis-associated colon cancer.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00242/fullColitisInflammationInflammasomeer stressGRP78Hepatic Steatosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Beichu eGuo Zihai eLi |
spellingShingle |
Beichu eGuo Zihai eLi Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases Frontiers in Genetics Colitis Inflammation Inflammasome er stress GRP78 Hepatic Steatosis |
author_facet |
Beichu eGuo Zihai eLi |
author_sort |
Beichu eGuo |
title |
Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases |
title_short |
Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases |
title_full |
Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases |
title_fullStr |
Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases |
title_full_unstemmed |
Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases |
title_sort |
endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2014-07-01 |
description |
As an adaptive response to the overloading with misfolded proteins in the endoplasmic reticulum (ER), ER stress plays critical roles in maintaining protein homeostasis in the secretory pathway to avoid damage to the host. Such a conserved mechanism is accomplished through three well-orchestrated pathways known collectively as unfolded protein response (UPR). Persistent and pathological ER stress has been implicated in a variety of diseases in metabolic, inflammatory and malignant conditions. Furthermore, ER stress is directly linked with inflammation through UPR pathways, which modulate transcriptional programs to induce the expression of inflammatory genes. Importantly, the inflammation induced by ER stress is directly responsible for the pathogenesis of metabolic and inflammatory diseases. In this review, we will discuss the potential signaling pathways connecting ER stress with inflammation. We will also depict the interplay between ER stress and inflammation in the pathogenesis of hepatic steatosis, inflammatory bowel diseases and colitis-associated colon cancer. |
topic |
Colitis Inflammation Inflammasome er stress GRP78 Hepatic Steatosis |
url |
http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00242/full |
work_keys_str_mv |
AT beichueguo endoplasmicreticulumstressinhepaticsteatosisandinflammatoryboweldiseases AT zihaieli endoplasmicreticulumstressinhepaticsteatosisandinflammatoryboweldiseases |
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1725742820940054528 |