Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study

Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study

Abstract Background Intestinal inflammation in Crohn’s disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired work productivity and significant health care costs. Not all patients respond to conventional a...

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Main Authors: John A. Snowden, Chris Hawkey, Daniel Hind, Lizzie Swaby, Katie Mellor, Richard Emsley, Laura Mandefield, Ellen Lee, Manuela Badoglio, Emmanuelle Polge, Myriam Labopin, John Gribben, A. Graham Pockley, Gemma A. Foulds, Alan Lobo, Simon Travis, Miles Parkes, Jack Satsangi, Diana Papaioannou, James O. Lindsay, on Behalf of the Autologous Stem Cell Transplantation In Refractory CD - Low Intensity Therapy Evaluation Study Investigators, the European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP)
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Gastroenterology
Subjects:
Crohn’s disease
Autologous stem cell transplant
Randomised controlled trial
Observational study
Online Access:http://link.springer.com/article/10.1186/s12876-019-0992-2

Internet

http://link.springer.com/article/10.1186/s12876-019-0992-2

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