Polymorphisms in CYP2E1, GSTM1 and GSTT1 and anti-tuberculosis drug-induced hepatotoxicity

Polymorphisms in CYP2E1, GSTM1 and GSTT1 and anti-tuberculosis drug-induced hepatotoxicity

Anti-tuberculosis drug-induced hepatitis (ATD- induced hepatitis) has been linked to polymorphisms in genes encoding drug metabolizing enzymes. N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1) and glutathione S-transferase (loci GSTM1 and GSTT1) are involved in the metabolism of isoniazid,...

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Bibliographic Details
Main Authors: TAIS C. BRITO, LIA G. POSSUELO, ANDREIA R.M. VALIM, PÂMELA F. TODENDI, ANDREZZA W. RIBEIRO, TATIANA S. GREGIANINI, CARLA A. JARCZEWSKI, MARA H. HUTZ, MARIA LUCIA R. ROSSETTI, ARNALDO ZAHA
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2014-06-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
Hepatotoxicidade
isoniazida
polimorfismos
tuberculose
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000200855&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000200855&lng=en&tlng=en

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