Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins

Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins

Abstract Background Tubulysins family is a kind of natural compound with potent, antitumor activity. To simplify the synthesis route and find new antitumor compounds is becoming a hotspot of research recent years. Results Starting from 3-nitrobenzoic acid, after 7 steps transformations, 12 new tubul...

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Bibliographic Details
Main Authors: Mingsha Shao, Xinfa Bai, Xuan Ma, Ning Yan, Lei Yao
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Chemistry Central Journal
Subjects:
Tubulysin
Analogues
Synthesis
Antitumor activity
Online Access:http://link.springer.com/article/10.1186/s13065-018-0483-5

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http://link.springer.com/article/10.1186/s13065-018-0483-5

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