Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer

Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer

Summary: We report a comprehensive molecular analysis of 34 cases of small cell carcinoma (SCC) and 84 cases of conventional urothelial carcinoma (UC), with The Cancer Genome Atlas cohort of 408 conventional UC bladder cancers used as the reference. SCCs showed mutational landscapes characterized by...

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Bibliographic Details
Main Authors: Guoliang Yang, Jolanta Bondaruk, David Cogdell, Ziqiao Wang, Sangkyou Lee, June Goo Lee, Shizhen Zhang, Woonyoung Choi, Yan Wang, Yu Liang, Gang Wang, Ying Wang, Hui Yao, Vipulkumar Dadhania, Jianjun Gao, Christopher Logothetis, Arlene Siefker-Radtke, Ashish Kamat, Colin Dinney, Dan Theodorescu, Marek Kimmel, Peng Wei, Charles C. Guo, John N. Weinstein, David J. McConkey, Bogdan Czerniak
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Biological Sciences
Genomics
Cancer Systems Biology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303862

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http://www.sciencedirect.com/science/article/pii/S2589004220303862

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