SILAC-based quantitative proteomics using mass spectrometry quantifies endoplasmic reticulum stress in whole HeLa cells

SILAC-based quantitative proteomics using mass spectrometry quantifies endoplasmic reticulum stress in whole HeLa cells

The unfolded protein response (UPR) involves extensive proteome remodeling in many cellular compartments. To date, a comprehensive analysis of the UPR has not been possible because of technological limitations. Here, we employ stable isotope labeling with amino acids in cell culture (SILAC)-based pr...

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Bibliographic Details
Main Authors: Daniel N. Itzhak, Francesca Sacco, Nagarjuna Nagaraj, Stefka Tyanova, Matthias Mann, Marta Murgia
Format: Article
Language:English
Published: The Company of Biologists 2019-11-01
Series:Disease Models & Mechanisms
Subjects:
proteomics
silac
unfolded protein response
endoplasmic reticulum stress
tunicamycin
Online Access:http://dmm.biologists.org/content/12/11/dmm040741

Internet

http://dmm.biologists.org/content/12/11/dmm040741

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