Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial

Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial

Abstract Background Optimal antimicrobial drug exposure in the lung is required for successful treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary pharmacokinetics (PK) of meropenem when administered by continuous infusion (CI). The aim of this study was to evaluate...

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Bibliographic Details
Main Authors: Adela Benítez-Cano, Sonia Luque, Luisa Sorlí, Jesús Carazo, Isabel Ramos, Nuria Campillo, Víctor Curull, Albert Sánchez-Font, Carles Vilaplana, Juan P. Horcajada, Ramón Adalia, Silvia Bermejo, Enric Samsó, William Hope, Santiago Grau
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Critical Care
Subjects:
Meropenem
Population pharmacokinetics
Pharmacodynamics
Critically ill patients
Nosocomial pneumonia
Lung penetration
Online Access:http://link.springer.com/article/10.1186/s13054-020-2763-4

Internet

http://link.springer.com/article/10.1186/s13054-020-2763-4

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