Polymorphic Region-Specific Antibody for Evaluation of Affinity-Associated Profile of Chimeric Antigen Receptor

Polymorphic Region-Specific Antibody for Evaluation of Affinity-Associated Profile of Chimeric Antigen Receptor

Antibody applications in cancer immunotherapy involve diverse strategies, some of which redirect T cell-mediated immunity via engineered antibodies. Affinity is a trait that is crucial for these strategies, as optimal affinity reduces unwanted side effects while retaining therapeutic function. Antib...

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Bibliographic Details
Main Authors: Chungyong Han, Beom K. Choi, Seon-Hee Kim, Su-Jung Sim, Seongeun Han, Bomi Park, Yohei Tsuchiya, Masaki Takahashi, Young H. Kim, Hyeon-Seok Eom, Tetsuya Kitaguchi, Hiroshi Ueda, Byoung S. Kwon
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
antibody
affinity
HLA-DR
polymorphism
T cell
chimeric antigen receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300541

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http://www.sciencedirect.com/science/article/pii/S2372770520300541

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