The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposide.

The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposide.

The mixed lineage leukaemia (MLL) gene is frequently rearranged in secondary leukaemias, in which it could fuse to a variety of different partners. Breakage in the MLL gene preferentially occurs within a ~8 kb region that possesses a strong DNA topoisomerase II cleavage site. It has been proposed th...

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Bibliographic Details
Main Authors: Sergey I Glukhov, Mikhail A Rubtsov, Daniil A Alexeyevsky, Andrei V Alexeevski, Sergey V Razin, Olga V Iarovaia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3783379?pdf=render

Internet

http://europepmc.org/articles/PMC3783379?pdf=render

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