St. John’s Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway

St. John’s Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway

St. John’s Wort (SJW) has been used as an estrogen agonist in the systems affected by menopause. Also, hypericin, a bioactive compound of SJW, has been used as a photosensitizer in photodynamic therapy. In the present study, we investigate the anti-proliferative and pro-apoptotic effects of SJW to d...

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Bibliographic Details
Main Authors: Mi-Kyoung You, Hwa-Jin Kim, Ji Hyun Kook, Hyeon-A Kim
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
St. John’s Wort
breast cancer
growth inhibition
AMPK/mTOR
mitochondrial pathway
Online Access:http://www.mdpi.com/1422-0067/19/4/966

Internet

http://www.mdpi.com/1422-0067/19/4/966

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