Single-Cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2

Single-Cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2

Aims: COVID-19 patients with comorbidities such as hypertension or heart failure (HF) are associated with poor clinical outcomes. The cellular distribution of Angiotensin-converting enzyme 2 (ACE2), the critical enzyme for SARS-CoV-2 infection, in the human heart is unknown. We explore the underlyin...

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Bibliographic Details
Main Authors: Mengqiu Ma, Yanhua Xu, Yang Su, Sang-Bing Ong, Xingdong Hu, Min Chai, Maojun Zhao, Hong Li, Xiaojuan Fan, Yingjie Chen, Dachun Xu, Xiaojiang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
COVID-19
SARS-CoV-2
heart failure
angiotensin converting enzyme 2
single-cell RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.628885/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.628885/full

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