BLM SUMOylation regulates ssDNA accumulation at stalled replication forks

BLM SUMOylation regulates ssDNA accumulation at stalled replication forks

Polymerase stalling results in uncoupling of DNA polymerase and the replicative helicase, which generates single-stranded DNA (ssDNA). After stalling, RAD51 accumulates at stalled replication forks to stabilize the fork and to repair by homologous recombination (HR) double-strand breaks (DSBs) that...

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Bibliographic Details
Main Authors: Karen J Ouyang, Michael J Matunis, Mary K Yagle, Nathan A Ellis
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Genetics
Subjects:
Homologous Recombination
Bloom’s syndrome
DNA repair foci
RecQ DNA helicases
replication fork stability
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00167/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00167/full

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