Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis

Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis

Abstract Background B cells play a central role in multiple sclerosis (MS) through production of injurious antibodies, secretion of pro-inflammatory cytokines, and antigen presentation. The therapeutic success of monoclonal antibodies (mAbs) targeting B cells in some but not all individuals sufferin...

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Bibliographic Details
Main Authors: Marc Y. Stevens, Haley C. Cropper, Katherine L. Lucot, Aisling M. Chaney, Kendra J. Lechtenberg, Isaac M. Jackson, Marion S. Buckwalter, Michelle L. James
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Neuroinflammation
Subjects:
PET
Multiple sclerosis
EAE mice
B cells
CD19
Online Access:http://link.springer.com/article/10.1186/s12974-020-01880-8

Internet

http://link.springer.com/article/10.1186/s12974-020-01880-8

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