Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution

Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution

Background: High-dose methotrexate (HD-MTX) with folinic acid (leucovorin) rescue is the gold standard therapy in the treatment of osteosarcoma. The plasma concentration of MTX is closely related to efficacy and toxicity. There are large individual differences. Many authors have described the pharma...

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Bibliographic Details
Main Authors: Wei Zhang, Qing Zhang, Xiaohuang Tian, Haitao Zhao, Wei Lu, Jiancun Zhen, Xiaohui Niu
Format: Article
Language:English
Published: Wolters Kluwer 2015-01-01
Series:Chinese Medical Journal
Subjects:
Methotrexate; Osteosarcoma; Population Pharmacokinetics
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=1;spage=111;epage=118;aulast=Zhang

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http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=1;spage=111;epage=118;aulast=Zhang

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