Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease

Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease

The development of a non-sputum-based, point-of-care diagnostic test for tuberculosis (TB) is a priority in the global effort to combat this disease, particularly in resource-constrained settings. Previous studies have identified host biomarker signatures which showed potential, but there is a need...

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Bibliographic Details
Main Authors: Hygon Mutavhatsindi, Gian D. van der Spuy, Stephanus T. Malherbe, Jayne S. Sutherland, Annemieke Geluk, Harriet Mayanja-Kizza, Amelia C. Crampin, Desta Kassa, Rawleigh Howe, Adane Mihret, Jacob A. Sheehama, Emmanuel Nepolo, Gunar Günther, Hazel M. Dockrell, Paul L. A. M. Corstjens, Kim Stanley, Gerhard Walzl, Novel N. Chegou, the AE-TBC ScreenTB Consortia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
bio-signature
diagnostic
validation
blood
biomarkers
point of care
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.607827/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.607827/full

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