The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats.

The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats.

Enzastaurin is a Protein Kinase C-β selective inhibitor that was developed to treat cancers. Protein Kinase C-β is an important enzyme for a variety of neuronal functions; in particular, previous rodent studies have reported deficits in spatial and fear-conditioned learning and memory with lower lev...

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Bibliographic Details
Main Authors: Mari N Willeman, Sarah E Mennenga, Ashley L Siniard, Jason J Corneveaux, Matt De Both, Lauren T Hewitt, Candy W S Tsang, Jason Caselli, B Blair Braden, Heather A Bimonte-Nelson, Matthew J Huentelman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5988320?pdf=render

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http://europepmc.org/articles/PMC5988320?pdf=render

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