Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons

Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons

SHANK3 mutations, including de novo deletions, have been associated with autism spectrum disorders (ASD). However, the effects of SHANK3 loss of function on neurodevelopment remain poorly understood. Here we generated human induced pluripotent stem cells (iPSC) in vitro, followed by neuro-differenti...

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Bibliographic Details
Main Authors: Guanqun Huang, Shuting Chen, Xiaoxia Chen, Jiajun Zheng, Zhuoran Xu, Abolfazl Doostparast Torshizi, Siyi Gong, Qingpei Chen, Xiaokuang Ma, Jiandong Yu, Libing Zhou, Shenfeng Qiu, Kai Wang, Lingling Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Neuroanatomy
Subjects:
induced pluripotent stem cells
neural stem cells
SHANK3
electrophysiology
RNA-Seq
autism
Online Access:https://www.frontiersin.org/article/10.3389/fnana.2019.00023/full

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https://www.frontiersin.org/article/10.3389/fnana.2019.00023/full

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