OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

Abstract Background Self-renewal is dependent on an intrinsic gene regulatory network centered on OCT4 and on an atypical cell cycle G1/S transition, which is also regulated by OCT4. p21, a gene negatively associated with self-renewal and a senescence marker, is a member of the universal cyclin-depe...

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Bibliographic Details
Main Authors: Yan Lu, Huinan Qu, Da Qi, Wenhong Xu, Shutong Liu, Xiangshu Jin, Peiye Song, Yantong Guo, Yiyang Jia, Xinqi Wang, Hairi Li, Yulin Li, Chengshi Quan
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Stem Cell Research & Therapy
Subjects:
hHFMSCs
OCT4
Self-renewal
Senescence
p21
DNMTs
Online Access:http://link.springer.com/article/10.1186/s13287-018-1120-x

Internet

http://link.springer.com/article/10.1186/s13287-018-1120-x

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