SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs). While many non-cullin neddylation substrates have been proposed over the years, validation of true NEDD8 targets has been challenging, as overex...

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Bibliographic Details
Main Authors: Kate E Coleman, Miklós Békés, Jessica R Chapman, Sarah B Crist, Mathew JK Jones, Beatrix M Ueberheide, Tony T Huang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
ubiquitin
CRL
Nedd8
Ubl protease
Ubc12
Online Access:https://elifesciences.org/articles/24325

Internet

https://elifesciences.org/articles/24325

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