Genetic profiling of primary and secondary tumors from patients with lung adenocarcinoma and bone metastases reveals targeted therapy options

Genetic profiling of primary and secondary tumors from patients with lung adenocarcinoma and bone metastases reveals targeted therapy options

Abstract Background Patients newly diagnosed with lung adenocarcinoma with bone metastases (LABM) have poor survival rates after treatment with conventional therapies. To improve outcomes, we retrospectively investigated whether the application of a more comprehensive genetic test of tumor biopsies...

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Bibliographic Details
Main Authors: Long Huang, Xiao-Liu Jiang, Hong-Bin Liang, Jian-Cheng Li, Li-Han Chin, Jian-Ping Wei, Rui-Ru Wang, Jing Cai, Qiang Xiong, Lien-Tu Wang, David S. Cram, An-Wen Liu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Medicine
Subjects:
Lung adenocarcinoma (LA)
Lung adenocarcinoma bone metastasis (LABM)
Epithelial growth factor receptor (EGFR), clonal evolution, capture single molecule amplification and resequencing technology (capSMART)
Online Access:http://link.springer.com/article/10.1186/s10020-020-00197-9

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http://link.springer.com/article/10.1186/s10020-020-00197-9

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