Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection

Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection

Proline racemase is an important enzyme of Trypanosoma cruzi and has been shown to be an effective mitogen for B cells, thus contributing to the parasite's immune evasion and persistence in the human host. Recombinant epimastigote parasites overexpressing TcPRAC genes coding for proline racemas...

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Bibliographic Details
Main Authors: Leticia Coutinho, Marcelo Alves Ferreira, Alain Cosson, Marcos Meuser Batista, Denise da Gama Jaén Batista, Paola Minoprio, Wim M Degrave, Armand Berneman, Maria de Nazaré Correia Soeiro
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2009-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Trypanosoma cruzi
proline racemase
host-parasite interaction
enzyme inhibition
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800001

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800001

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