Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39

Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39

Extracellular ATP mediates proinflammatory and antiproliferative effects via activation of P2 nucleotide receptors. In contrast, its metabolite, the nucleoside adenosine, is strongly immunosuppressive and enhances tumor proliferation and metastasis. The conversion of ATP to adenosine is catalyzed by...

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Bibliographic Details
Main Authors: Vittoria Lopez, Laura Schäkel, H. J. Maximilian Schuh, Michael S. Schmidt, Salahuddin Mirza, Christian Renn, Julie Pelletier, Sang-Yong Lee, Jean Sévigny, Susanne Alban, Gerd Bendas, Christa E. Müller
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Marine Drugs
Subjects:
adenosine
CD39
ectonucleotidase inhibitors
fucoidan
immuno-oncology
NPP1
Online Access:https://www.mdpi.com/1660-3397/19/2/51

Internet

https://www.mdpi.com/1660-3397/19/2/51

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