Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

Abstract Background Tafenoquine was recently approved for Plasmodium vivax radical cure (KRINTAFEL™) and malaria prevention (ARAKODA™). Methods A review of the non-clinical and clinical literature was conducted to assess whether tafenoquine (and primaquine) exhibit the same neurologic lesions and as...

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Bibliographic Details
Main Authors: Jonathan Berman, Tracey Brown, Geoffrey Dow, Stephen Toovey
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Malaria Journal
Subjects:
8-aminoquinoline
Neurotoxicity
Brain-stem
Neurohistopathology
Malaria
Primaquine
Online Access:http://link.springer.com/article/10.1186/s12936-018-2555-3

Internet

http://link.springer.com/article/10.1186/s12936-018-2555-3

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