The Gly482Ser Missense Mutation of the Peroxisome Proliferator-Activated Receptor γ Coactivator-1α (PGC-1α) Gene Associates with Reduced Insulin Sensitivity in Normal and Glucose-Intolerant Obese Subjects

The Gly482Ser Missense Mutation of the Peroxisome Proliferator-Activated Receptor γ Coactivator-1α (PGC-1α) Gene Associates with Reduced Insulin Sensitivity in Normal and Glucose-Intolerant Obese Subjects

Among the putative candidate genes for insulin resistance, the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a transcriptional coactivator of PPARγ and α, regulating a wide range of processes involved in energy production and utilization, such as thermogenesis, liver glucon...

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Bibliographic Details
Main Authors: Marzia Fanelli, Emanuela Filippi, Federica Sentinelli, Stefano Romeo, Mara Fallarino, Raffaella Buzzetti, Frida Leonetti, Marco Giorgio Baroni
Format: Article
Language:English
Published: Hindawi Limited 2005-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2005/576748

Internet

http://dx.doi.org/10.1155/2005/576748

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