Etoposide induces nuclear re-localisation of AID.

During B cell activation, the DNA lesions that initiate somatic hypermutation and class switch recombination are introduced by activation-induced cytidine deaminase (AID). AID is a highly mutagenic protein that is maintained in the cytoplasm at steady state, however AID is shuttled across the nuclea...

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Bibliographic Details
Main Authors: Laurens J Lambert, Simon Walker, Jack Feltham, Heather J Lee, Wolf Reik, Jonathan Houseley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3852760?pdf=render