NSP2 Is Important for Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus to Trigger High Fever-Related COX-2-PGE2 Pathway in Pigs

NSP2 Is Important for Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus to Trigger High Fever-Related COX-2-PGE2 Pathway in Pigs

In 2006, atypical porcine reproductive and respiratory syndrome (PRRS) caused by a highly pathogenic PRRSV (HP-PRRSV) strain broke out in China. Atypical PRRS is characterized by extremely high fever and high mortality in pigs of all ages. Prostaglandin E2 (PGE2) derived from arachidonic acid throug...

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Bibliographic Details
Main Authors: Li Du, Honglei Wang, Fang Liu, Zeyu Wei, Changjiang Weng, Jun Tang, Wen-hai Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
HP-PRRSV
NSP2
fever
PGE2
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.657071/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.657071/full

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