Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies

Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies

Abstract Background Activation of silent biosynthetic gene clusters (BGCs) in marine-derived actinomycete strains is a feasible strategy to discover bioactive natural products. Actinoalloteichus sp. AHMU CJ021, isolated from the seashore, was shown to contain an intact but silent caerulomycin A (CRM...

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Bibliographic Details
Main Authors: Yunchang Xie, Jiawen Chen, Bo Wang, Tai Chen, Junyu Chen, Yuan Zhang, Xiaoying Liu, Qi Chen
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Microbial Cell Factories
Subjects:
Caerulomycin A
Genome mining
Combinatorial strategies
Ribosome engineering
Strain improvement
Marine-derived Actinoalloteichus
Online Access:http://link.springer.com/article/10.1186/s12934-020-01418-w

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http://link.springer.com/article/10.1186/s12934-020-01418-w

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